PPARγ- Novel Target in Antidiabetic Drug Design
نویسندگان
چکیده
The nuclear receptors constitute one of the largest groups of transcription factors known today. The peroxisome proliferator-activated receptors (PPAR) are members of the nuclear receptor supergene family and are considered as key sensors of both lipid and glucose homeostasis. The role of the PPAR γ isoform in glucose metabolism is illustrated by the fact that antidiabetic thiazolidinediones have been shown to be bonafide PPARγ ligands. The present review has established the PPARs as molecular target for the design and development of antidiabetic drugs.
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